Kagocel pharmacological action. Antiviral drug Kagocel: efficacy and dosages
The main mechanism of action of Kagocel is the ability to induce the production of interferon. It causes the formation in the human body of the so-called. late interferon, which is a mixture of alpha and beta interferons with high antiviral activity.
Stimulates the production of physiological amounts of interferon gamma. It causes the production of interferon in almost all populations of cells involved in the antiviral response of the body: T- and B-lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells.
When administered in therapeutic doses, it is non-toxic and does not accumulate in the body. The drug does not possess mutagenic and teratogenic properties, is not carcinogenic and does not have an embryotoxic effect.
For preventive purposes, the drug can be used at any time, incl. and immediately after contact with a source of infection.
Kagocel instructions for use
Tradename - Kagocel(Kagocel)
Country of origin - Russia.
The manufacturer is Nearmedic-Plus CJSC.
Forms of release and composition
Kagocel tablets... 1 tablet contains Kagocel - 12 mg / 25 mg.
In a contour acheikova package 10 pcs., In a cardboard box 1 package.
Excipients: potato starch, calcium stearate, lactose.
Composition by components: kagocel, lactose, calcium stearate, potato starch.
Indications for use
Kagocel is effective in the treatment of diseases caused by viruses: influenza, ARVI (acute respiratory viral infections). Also, the drug is used to treat herpes, urogenital chlamydia.
The drug is used for the treatment of adults and children over the age of 6 years with various diseases of viral etiology, including:
- prevention and treatment of influenza and other acute respiratory viral infections in adults;
- treatment of influenza and other acute respiratory viral infections in children from 6 years of age and older;
- treatment of herpes in adults.
The drug can also be used in the complex treatment of urogenital chlamydia.
In addition, the drug can be used as a prophylactic agent during epidemics of acute respiratory viral infections and influenza.
Pharmacological group
- Antiviral (excluding HIV) drugs.
- Interferon inducers.
pharmachologic effect
When a single dose of Kagocel is taken orally, the interferon titer in the blood serum reaches its maximum values after 48 hours. The body's interferon response to the administration of Kagocel is characterized by prolonged (up to 4-5 days) circulation of interferon in the bloodstream. The dynamics of the accumulation of interferon in the intestine when taking the drug inside does not coincide with the dynamics of the titers of circulating interferon. In the blood serum, the interferon content reaches high values only 48 hours after taking Kagocel, while in the intestine, the maximum production of interferon is noted already after 4 hours.
When administered in therapeutic doses, Kagocel is non-toxic and does not accumulate in the body. The drug does not possess mutagenic and teratogenic properties, is not carcinogenic and has no embryotoxic effect.
Method of administration and dosage
For the treatment of influenza and SARS for adults prescribed in the first two days - 2 tablets 3 times a day, in the next two days - one tablet 3 times a day. In total, the course is 18 tablets, the duration of the course is 4 days.
Prevention of respiratory viral infections in adults carried out in 7-day cycles, two days - 2 tablets 1 time per day. 5 days off, then the cycle was repeated. The duration of the preventive course is from one week to several months.
For the treatment of herpes in adults but 2 tablets are prescribed 3 times a day for 5 days. All for the course - 30 tablets, the duration of the course - 5 days.
For the treatment of influenza and ARVI for children aged 6 years and older appoint in the first two days - 1 tablet 3 times a day, in the next two days - one tablet 2 times a day. In total for the course - 10 tablets, the duration of the course - 4 days.
Prevention of influenza and ARVI in children aged 6 years and older carried out in 7-day cycles: two days - no 1 tablet once a day. 5 days break, then repeat the cycle. The duration of the preventive course is from one week to several months.
Contraindications
Kagocel is contraindicated if the patient has hypersensitivity to the components of the drug, which is of an individual nature. Also, this drug is not used to treat children under the age of six.
Hereditary intolerance to galactose, lactase deficiency Lapa, impaired absorption of glucose-galactose.
special instructions
The greatest efficiency in the treatment of Kagocel is achieved when it is administered no later than the 4th day after the onset of an acute infection. For preventive purposes, the drug can be used at any time, incl. and immediately after contact with the infectious agent. Kagocel combines well with other antiviral drugs, immunomodulators and antibiotics.
Side effects
Usually, the drug is well tolerated by patients; in very rare cases, allergic reactions may develop.
Interaction
With the simultaneous use of Kagocel with other antiviral drugs, immunomodulators and antibiotics, an additive effect has been described.
Pregnancy and lactation
The drug is not used for the treatment of women during pregnancy and lactation.
Childhood
The drug is not used to treat children under the age of 6 years.
Shelf life
2 years. After the expiration date, the drug should not be used.
Storage conditions
In a dry, dark place at a temperature not exceeding 25 C. Keep out of the reach of children.
Terms of dispensing from pharmacies
Without a doctor's prescription.
Kagocel price
Kagocel tablets 12 mg, 10 pcs., NEARMEDIC Plus, LLC = 188.78 rubles.
Kagocel reviews
Compared to Arbidol, it is slightly more expensive than 220 rubles for 10 tablets. But as for everything else, the tone is in no way inferior to Arbidol. There are no contraindications other than allergies. It is non-toxic and does not accumulate in the body. It is used for the prevention and treatment of ODS and influenza. They drink it in courses, but as for myself, I drank it when I felt that I was starting to get sick. I drank 2 tablets and the disease receded. And if you do the right thing, then it is recommended to take it as follows. Two days, 2 tablets 1 time per day, 5 days off, then repeat the cycle. Reliably protects against flu and colds.
I have already tried Kagocel several times. very happy. really need to read the instructions. my daughter had purulent tonsillitis, her temperature was under 40. They took two days, the first day, 3 tablets 3 times a day, the second day, 2 times a day, 2 tablets. squeezed lemon juice into hot water, drank several times a day. did not drink anything else. there was no temperature by the evening, and on the second day there were no symptoms of the disease at all. That is, Kagocel fights the virus and side effects such as fever. yesterday I felt very bad, temperature 38.2, chills, weakness. I also drank kogotsel and lemon juice with hot water, today I calmly went to work, but kagocel drank the second day. I feel great!
A wonderful drug. Last winter, the whole family drank for prophylaxis, no one got sick. A friend drank from herpes, for almost a year she does not remember what kind of infection it is. Recently I bought it at a pharmacy, so the pharmacist said that now Kagocel's intake is possible in children from the age of three. So far, the old packages are not written, but she showed the official paper on the changes to the instructions.
Anyone who has had herpes knows what unpleasant sensations it is and how it spoils life, and if a sore appears 4 times during the winter, then this is not at all funny. It was so with me. She began to be treated with Kagocel on the recommendation of a doctor, the wound dries up quickly, it burns and itches less. This winter there was no herpes yet (pah-pah).
With carboxymethyl cellulose) - 12 mg;
Release form
In pharmacy kiosks, the medicine can be found in the form of biconvex round tablets of cream or brown color with small splashes. The contoured cell blister contains 10 pieces. 1 plate is put into a carton box.
pharmachologic effect
Kagocel (INN - International Non-Proprietary Name) is an antiviral drug that is a synthetic complex organic sodium salt obtained by synthesis from water-soluble Carmoxymethylcellulose and Cottonseed Polyphenol. That is, the biologically active component of the drug is based on a certain proportion plant compounds .
Interferon titer in serum rises gradually and reaches maximum figures 48 hours after using the tablets. V intestines the dynamics of the accumulation of antiviral proteins is much higher - maximum interferon production celebrated after 4 hours. Therefore, it is recommended to monitor the effectiveness of the use of the drug by examining the contents of the lumen of the digestive tube and the activity of its cellular structures.
Therapeutic effect characterized as long-term, since the response of interferons persists during 4-5 days , during which protective proteins continue to circulate in the bloodstream of the great and small vessels. Due to this property, the greatest efficiency in conservative treatment with a pharmaceutical preparation is observed when it is administered no later than the 4th day from the onset of the acute course of the infectious process.
Indications for use
- prevention of colds ;
- simple in the adult category of patients.
Contraindications
- increased individual sensitivity to the constituent components of a pharmaceutical preparation;
- period and ;
- hereditary or acquired intolerance medicinal product;
- age category of patients under 3 years old;
- enzymatic disorders digestive system - lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Side effects
Adverse effects from the use of the drug are extremely rare and, as a rule, are limited ... However, if the patient observes any side effects of the active ingredients of the pharmaceutical preparation, you should immediately seek the advice of a qualified doctor.
Instructions for use of Kagocel (Way and dosage)
Kagocel tablets, instructions for use
In the annotation, the manufacturer indicates that the drug should be used orally , not chewing the pill, but swallowing it whole. You can drink a sufficient amount of liquid, but do not keep it in the mouth for a long time. The dosage and duration of treatment, as a rule, are individually selected empirically, but there are also general therapeutic regimens that should be considered by the attending physician as practical recommendations.
How to drink for adults?
For therapeutic purposes for acute respiratory viral infections , or flu-like diseases are prescribed 2 tablets 3 times a day for the first 2 days, and the next 2 days, 1 tablet 3 times a day. The course dosage is 18 tablets, and the duration of treatment is 4 days. How to take - before or after meals - is of no practical importance for an adult organism, since the absorption capacity of biologically active components of a pharmaceutical preparation does not change with the entry of food into the cavity of the gastrointestinal tract.
The drug can also be used as preventive , preventive readjustment which is carried out in 7-day cycles. The course is divided into two phases. The first, active, when 2 tablets are prescribed 1 time per day for 2 days, and the second, passive, is a 5-day break (the time during which the active components are able to realize their therapeutic effects). Then, if necessary, you can repeat the prophylactic course of treatment.
Instructions for use for children
In the age category from 3 to 6 years old - 1 tablet 2 times a day in the first 2 days, and in the next 2 days, 1 tablet once a day. In total, the children's therapeutic course for the smallest is 6 tablets with a duration of 4 days.
Aged more than 6 years appoint 1 tablet 3 times a day in the first 2 days, and in the next 2 days - 1 tablet 2 times a day. Accordingly, the duration of conservative sanitation has not changed and is 4 days, and the dosage of the pharmaceutical product has increased to 10 tablets.
The drug can be used for prophylactic purposes and in pediatric practice. The two-phase regimen for taking the drug remains, however, the dosage is reduced to 1 tablet 1 time per day for the first 2 days.
How to take Kagocel for herpes?
Since the pharmaceutical action of Kagocel extends to viruses and the immune system, accordingly, the drug can be used by the adult category of patients not only for the treatment of colds of viral etiology, but also for the elimination of unpleasant herpes sores. How to drink pills for herpes - 2 tablets are prescribed 3 times a day for 5 days. Heading dose - 30 tablets.
Overdose
As with side effects, the clinical state of overdose is very rare and is accompanied by bouts of nausea and pain in the upper abdomen. In the event of these symptoms, it is recommended to clear the gastrointestinal tract from Kagocel tablets using artificially induced vomiting. Further, an abundant drink and some other elements are prescribed. detoxification therapy .
Interaction
No clinically significant interactions have been identified or described in the medical literature at this time.
Terms of sale
Annotation to the drug claims that the tablets are freely available in pharmacy kiosks, that is, the drug can be purchased without a prescription.
Storage conditions
Keep tablets out of the reach of children at a temperature not exceeding 25 degrees Celsius.
Shelf life
special instructions
Is Kagocel an antibiotic or not?
The drug has strong antimicrobial, antiviral and immunomodulatory therapeutic effects, from which the tablets can be perceived by ordinary people as. But from the point of view of clinical pharmacology, this is not entirely true, because in the definition of this group of pharmaceutical products, the key is the natural or semi-natural origin of the active ingredients. Kagocel, in turn, is synthetic derivative herbal ingredients, which allowed research scientists to combine the best qualities of anti-cold drugs in one tablet.
Kagocel's analogs
Matching ATX level 4 code:Also, as analogues of Kagocel, many pharmaceutical preparations are considered that do not have an identical therapeutic effect, but are similar in the final result to an anti-cold antiviral drug.
Which is better: Kagocel or Ingavirin?
Is a popular winter pharmaceutical product, characterized by a pronounced antiviral effect against the most common causative agents of acute respiratory diseases, such as influenza A and B viruses and influenza couple, respiratory syncytial group of viruses, and many others. The mechanism of its action is based on the ability of biologically active components to influence reproductive processes and the resumption of malicious agents. Also, the drug in the form of capsules is credited with a strong anti-inflammatory effect on the human body.
Undoubtedly, the pharmaceutical preparation is effective in the course of conservative sanitation of colds with a confirmed origin of the pathogen, however, as nonspecific therapy when it is not possible to establish the etiological component of the pathology, the use of Ingavirin is not rational. Kagocel wins in another way, namely preventive measures , because the drug is actively used to prevent the development of respiratory infections in winter, which, unfortunately, Ingavirin cannot boast of.
Which is better: Kagocel or Arbidol?
, like Kagocel, is an antiviral drug, the therapeutic feasibility of using which is to increase the production of natural interferon, which counteracts the invasion of pathological agents. In addition, the active components of the drug stimulate the cellular and humoral reactions of the immune system, which has a positive effect on the body's resistance to viral respiratory infections.
The list of side effects of Arbidol is as short as that of Kagocel, but unlike the latter, the pharmaceutical preparation is included in list B (register of medicines, the appointment of which should be made with extreme caution, since unforeseen complications may develop when using them without careful medical supervision), which in itself is alarming. If a decision is made to undergo conservative therapy or preventive sanitation "on the feet" (without issuing an official sick leave), then you should definitely choose Kagocel.
Which is better: Kagocel or Amiksin?
It is an effective synthetic inducer of interferon, that is, the mechanism of action is similar to Kagocel tablets, since the drug increases the formation of an active antiviral agent by intestinal epithelial cells, hepatocytes, and some fractions of lymphocytes. A distinctive feature of Amiksin is the speed of the offensive therapeutic effects , a mild immunomodulatory effect is observed within 4-24 hours after taking the drug. Accordingly, its use is more rational in urgent conservative readjustment patients of the adult age category.
V pediatric practice the pharmaceutical product has not gained such wide popularity, since the annotation contains a contraindication to the use of tablets Amiksin up to 7 years. This means that when treating children of the younger age segment, preference should be given to Kagocel, the use of which can be started as early as 3 years old.
Kagocel or Ergoferon - which is better?
Ergoferon Is a drug with an unusually broad spectrum of therapeutic action, which, in addition to selective antiviral and immunomodulatory effects, includes antihistamines and anti-inflammatory Components. The clinical rationality of the use of a pharmaceutical product has been proven on many points. So, for example, the list of pathogens of respiratory infectious diseases that are defeated after using Ergoferon tablets is much larger than that of Kagocel.
Separately, it should be noted that Ergoferon can be used both in therapeutic practice for adult patients and in pediatrics, starting from the age of 6 months. Based on these facts, the pharmaceutical product can be recognized as better than Kagocel, but the price of analogues of this level is, of course, higher.
Kagocel for children
The pharmaceutical product is actively used in pediatric practice, since its therapeutic spectrum covers one of the broadest parts of pediatric nosology. Acute respiratory diseases of an infectious, bacterial or any other origin are found all the time, because Kagocel is prescribed for children from the age of 3. Annotation to the drug assures the safety of such an early use of the drug, and grateful reviews from parents only confirm this fact.
How to take for children, you can find out in the paragraph with the instructions, which indicates the exact dosages of the pharmaceutical product for different ages. You should also pay attention to the possibility of prophylactic use of the drug to prevent the development of colds and acute respiratory diseases, which are ubiquitous in childhood.
Kagocel and alcohol
According to the mechanism of action and pharmacokinetic abilities of the active components of Kagocel, the drug does not directly interact with the components of alcoholic beverages. But endogenous interferons , produced under the influence of antiviral pills, have a negative, inhibitory influence on the central nervous system. That is, immune agents are capable of provoking the development of certain psychological and neurological disorders (especially often - retinopathies , neuropathies , lingering etc).
As a rule, such adverse consequences of conservative treatment are manifested asthenic disorders - excessive fatigue, weakness, decreased attention, impaired ability to concentrate , however, against the background of an acute respiratory disease, such side effects are not noticed, because they are similar to the clinical symptoms of almost any cold nosological unit.
If alcohol and Kagocel are mixed, then such manifestations are mutually reinforced (for the effect of alcoholic beverages on the central nervous system of a person, an inhibitory effect is characteristic), therefore at least 5 days must pass between the end of conservative treatment and the use of alcoholic beverages.
During pregnancy and lactation
There have been no reliable clinical studies on the effect of the active ingredients of a pharmaceutical product on a woman's body and a child developing in her womb, therefore, the decision to use the drug is made on an individual basis. Most practicing doctors are inclined to replace pills with other antiviral drugs during pregnancy and include this condition of the female body in contraindications to the use of Kagocel. A similar opinion of qualified specialists and about breastfeeding - if possible, the use of this drug should be avoided.
Reviews about Kagocele
The antiviral pharmaceutical product is very popular among patients in the pulmonary and therapeutic departments. The reason lies in the particular mechanism of action of Kagocel and, of course, in its clinical effectiveness, because for a relatively short conservative course of treatment of 7 days, the drug allows you to completely eliminate acute respiratory disease and significantly improve the quality of life in winter.
Separately, it is worth noting the doctors' reviews about Kagocel, since qualified medical specialists recommend using these tablets primarily for preventive sanitation of the bronchopulmonary system. The active components make it possible to increase the production of interferon several times, that is, they supply the body with methods of fighting against viruses and other harmful agents, which has such a significant therapeutic effect of the use of a pharmaceutical preparation.
Pills are used not only for the adult category of patients, but also for children, reviews of Kagocel on forums devoted to pediatric topics should also be taken into account when it comes to this drug. Reviews of parents, as a rule, are full of positive emotions and grateful words, because Kagocel is used from the age of 3 years, respectively, the child can safely go to kindergarten or elementary grades of elementary school, without fear of another respiratory infection or viral invasion.
Kagocel is approved by the majority of parents and for the absence of severe side effects. Conservative treatment with the drug is almost painless, if you do not take into account possible minor allergic reactions ... Also, the release form does not have an unpleasant odor or taste, that is, you will not have to make any special efforts to sanitize children, even the youngest age.
Kagocel's price where to buy
Like the cost of antiviral analogues, the price of Kagocel may differ from the place of purchase of the pharmaceutical product. The Russian Federation can boast of a lower price category of the drug, because it is produced at its factories. Indicative is the price of Kagocel in St. Petersburg, which is about 180 rubles. In the capital, you can buy it for 200 rubles.
The price of Kagocel in Ukraine is much higher, because there is a need to transport the drug over long distances. A variation of the pharmaceutical product for adults can be purchased in the range from 150 to 180 hryvnia. But how much does a children's Kagocel cost in the nearest pharmacy, it is recommended to find out in advance, since its use in pediatric practice is somewhat narrower, which may adversely affect the price.
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Kagocel tab. 12mg n10Nearmedic Pharma LLC
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Kagocel 12 mg n10 tabNearmedic Pharma LLC
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Note!
Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before using the drug Kagocel, be sure to consult with your doctor.Reviews
Razvodilovo, effect zero
Antiviral agent Tiloram. I will share my experience about this drug, maybe someone will help. Due to my age, I probably am 54 years old, I have a rather weak immunity and I often, especially in the cold season, suffer from ARVI and ARI, of course I was treated with a lot of things from expensive to more budgetary ones: Kagocel, Arbidol, Ingoverin and others, which helped quickly, which are not very, one might say passed by itself. I constantly change the means, so that there is no addiction, any drug helps more effectively if you use it for the first time. Once again, ill at the pharmacy, I bought a new drug, I had not used it before with an average price category ... not very cheap, but also not too expensive. It is produced by our domestic company Ozone. Only six tablets, medium size, in a small plastic jar, tightly closed with a cotton swab inside. The regimen is not complicated, sometimes it is necessary to take a pill every 6 hours, there is no ... one per day for the first two days and then generally one every two days. I took these pills according to the instructions, it became easier for me already on the third day, this is, compared to other similar drugs for my body, quite quickly, but of course there is still a lot of warm drinks and bed rest. The general impression is that I am satisfied. In the approach of winter and cold weather, I will definitely use tiloram for the purpose of prevention, I will definitely unsubscribe.)
Tatyana, these are two different things. Paracetamol is symptomatic - it brings down the temperature. Kagocel stimulates the immune system to fight the virus. acts on the cause, not the consequences.
I read reviews and ohererevay ...))) How can you compare paracetamol and other antipyretics with kagocel .. People, do not be stupid already ...
Maryana, Kagocel is indicated for viral infections and has an antiviral effect. Before starting treatment, it is necessary to establish the nature of the infection - a virus or a bacterium. To do this, you need to do an analysis. If your child had the virus, then the antiviral should have helped. Kagocel is quite effective in treatment. Since you have a cough, it can be assumed that the child originally had a bacterial infection - in such cases, no antiviral will help. It was necessary to start treatment with antibiotics. And in general, self-medication is the latter. what to do, you need to see a doctor.
Kristina September 4, 2015 5:17 pm
Kagocel is a very good drug, I personally have not found anything better for myself, I take it for preventive purposes, so I practically do not get sick with colds and flu, I believe that you need to worry about your body in advance, and not when it gets hot. Although I know that many people are treated with it, it is also very effective. But, unfortunately, Kagocel is not a panacea and for absolutely everyone a priori it could not be ideal. The instruction warns that it is contraindicated for people with hypersensitivity to the components of the drug, apparently the reason for Marusya's discomfort is precisely this.
Be careful with this drug. After taking 1 tablet, after 10 minutes I became red like cancer, my heart jumped out of my chest, called an ambulance - as a result, after pre-dozol and the medical officer was taken to the hospital. On the way, the redness disappeared, but they wanted to leave for examination, wrote a written refusal. However, since then I drink only 1/4 of new drugs and look at the reaction ...
All amiksins, arbidols, interferons, ingavirins, viferons and kagocels are personal business projects of officials who under the guise of chopping grandmothers. The sale of these "drugs" is not possible in normal countries because they will NEVER be registered without clinical trials. We have built a packing machine, made pills and sell them to anyone you want. They do not harm at best, but they certainly do not cure. Think about why you are drinking any incomprehensible and at the same time insanely expensive chemicals that have absolutely no effect.
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Kagocel refers to antimicrobial agents for systemic use, namely antiviral drugs. The name of the pharmacological group, where Kagocel enters, includes immunomodulators, so the medicine has two active directions.
The drug is able to provide antiviral, antimicrobial, immunomodulatory effects, stimulating the production of interferon, which is the main non-specific immune factor.
In addition, the drug stimulates the synthesis of alpha, beta and gamma interferons, the action of which is aimed at inhibiting the production of RNA and virus proteins. In addition, there is a direct and indirect activity of interferons against tumor cells.
The therapeutic effect after the first intake of Kagocel is noted after 4 hours, after which a high level of interferons is maintained for up to 4-5 days. The drug does not have a toxic effect on the body and does not accumulate in tissues, provided that the recommended dosages are observed.
Kagocel is a powerful antiviral drug that stimulates the production of interferons and activates the immune system. In addition, the drug is considered an immunomodulator, which also has a detrimental effect on the course of the disease.
, , ,
ATX code
J05AX Other antiviral drugs
Active ingredients
Pharmacological group
Antiviral agents
pharmachologic effect
Immunomodulatory drugs
Antiviral drugs
Indications for use of Kagocel
Based on the main therapeutic properties of the drug, it is possible to identify diseases in which the drug will be most effective.
So, the indications for the use of Kagocel implies its use in adults to prevent infection and treat the pathology of the viral nature of the occurrence. Most often, the medication is used for influenza infection and other respiratory pathologies of viral origin.
In childhood (from 3 to 6 years old), Kagocel is allowed to be used only for therapeutic purposes in viral diseases. In particular, the drug is effective for ARVI with manifestations of rhinitis or nasopharyngitis.
As for older children (from 6 years old), then Kagocel can be used with them not only with a therapeutic direction, but also prophylactically. It is especially important to use the medicine in the winter, when the child's body is weakened and prone to frequent viral attacks, as well as when a flu epidemic is approaching.
Indications for the use of Kagocel also include the treatment of herpes infection in adults with its frequent clinical manifestations in the form of rashes and general symptoms (fever, weakness, headache and joint aches). In addition, the drug is effective for combined infection in the presence of a respiratory disease and the activity of the herpes pathogen.
As an auxiliary drug, Kagocel is used in the treatment of urogenital chlamydia.
Release form
The main active ingredient of the drug is Kagocel. Of the auxiliary components, it is worth highlighting potato starch, calcium stearate, Ludipres (lactose monohydrate, crospovidone, povidone).
The release form of Kagocel is presented as a tablet preparation. Each tablet contains 12 mg of Kagocel, which allows you to strictly observe the dosage and avoid the occurrence of adverse reactions and overdose.
The main physicochemical properties of the drug are round shape, convex surface on both sides, as well as color - from light cream to brown with small inclusions.
This form of release does not allow the use of the drug in children under 3 years of age, however, each tablet contains a certain amount of the active substance, which ensures that the medication is taken without dividing the tablet into parts.
The tablet form of the drug is convenient to use, since it is strictly dosed and does not cause a large number of adverse reactions.
Pharmacodynamics
Kagocel is an antiviral drug, which determines its mechanism of action. The medicine is a stimulant for the production of interferon.
Pharmacodynamics Kagocel provides the production of late interferon, represented by a combination of alpha and beta interferons, which are characterized by a powerful antiviral effect. Kagocel stimulates its production in all cells responsible for the immune response. Among them, the most active are lymphocytes (T- and B-), granulocytes, endothelial and macrophage cells, as well as fibroblasts.
After a single intake of one dose of the drug, the interferon titer increases to a maximum level after two days. In the future, interferons circulate through the bloodstream for 4-5 days.
Pharmacodynamics Kagocel has a powerful antiviral, antimicrobial and immunomodulatory effect if the drug is used no later than 4 days after the acute onset of an infectious disease. To prevent illness, the drug can be taken at any time, especially after contact with an infectious source.
Pharmacokinetics
The drug is used for oral administration, after a single dose of which the activation of interferon production is observed and after 48 hours it reaches the maximum level.
When used orally, only 20% of the dose of the drug enters the general bloodstream. After a day, the main active substance of the drug accumulates in the tissue of the liver and lungs, thymus gland, urinary organs and lymph nodes.
Pharmacokinetics of Kagocel causes a small accumulation in muscles, plasma part of blood, myocardium, brain tissues, testes and adipose tissue. The low content of the active substance in the brain is due to the significant molecular weight of the drug, as a result of which it is unable to penetrate the BBB.
The drug is transported through the bloodstream in a bound state. So, its carriers can be lipids that bind kagocel by 47%, as well as proteins - up to 37%. The remaining 16% of the drug is the unbound portion.
With regular intake of the medication for 5-7 days, the pharmacokinetics of Kagocel provides the maximum grouping of the active substance in the spleen and nodes of the lymphatic system.
The process of drug elimination is carried out mainly through the digestive tract. A week after the start of using the medication, 90% of the accumulated volume of the medication is excreted from the body. The intestine removes 90% of the drug, and the kidneys - the remaining 10%. The excretion of Kagocel by the respiratory system was not detected.
Use of Kagocel during pregnancy
Throughout pregnancy, a woman's body undergoes cardinal changes affecting almost all organs and systems. All 9 months from a pregnant woman, tremendous strength is required to ensure optimal conditions for the full growth and development of the fetus.
In addition to changes in the hormonal background, mammary glands and organs of the female reproductive system, a woman's immunity also lends itself to great "tests".
The use of Kagocel during pregnancy is contraindicated in view of the fact that the drug has an immunostimulating effect, which can negatively affect the course of pregnancy and the health of the fetus.
Despite the fact that the formation of organs is observed during the first three months of pregnancy, they still grow and develop during the rest of the time.
The use of Kagocel during pregnancy is prohibited at any time in order to avoid the threat of termination of pregnancy and deterioration of the condition of both the pregnant woman and the fetus.
In addition, the medicine is not allowed for use during the period when the baby is breastfed. When a woman takes the drug, the risk of the active ingredient entering the milk and, accordingly, to the baby increases, which is unacceptable at his age.
Contraindications
Due to the fact that each organism is unique, reactions to taking a drug can also be completely different. The presence of such manifestations is due to the individual characteristics of the organism. One of the contraindications to the use of Kagocel is considered to be a person's hypersensitivity to the main active ingredient or auxiliary components.
In addition, contraindications to the use of Kagocel include children under 3 years of age, however, it is not recommended to use the medicine for prophylactic purposes until 6 years old, only for the treatment of infectious respiratory diseases.
One of the most important contraindications is the period of pregnancy and breastfeeding of the baby, since the use of Kagocel can have a negative impact on the course of pregnancy and the health of the fetus.
It is worth remembering that the drug cannot be used by people who have a lactase deficiency or intolerance to this enzyme. In addition, glucose-galactose malabsorption is considered a contraindication.
Contraindications to the use of Kagocel imply a ban on the use of such drugs, if the history has already noted adverse reactions to taking the drug.
Side effects of Kagocel
Depending on the composition of the drug and the heredity of the person, side effects from the drug may occur when using it. After a single or several doses of Kagocel, a person may experience an allergic reaction.
Its main clinical symptoms are systemic manifestations in the form of weakness, dizziness, headache, nausea and abdominal pain. Side effects of Kagocel can be manifested exclusively by rashes on the skin, a tingling sensation, itching, increased sensitivity and slight swelling.
Side effects of Kagocel can manifest themselves at any age, depending on the level of sensitivity of the organism and the predisposition inherent in genetics.
As soon as any clinical symptoms not characteristic of Kagocel are observed, its further use must be discontinued. In addition, you should contact a specialist to conduct a study and exclude an overdose.
In general, Kagocel is well tolerated, provided that the dosage and recommendations for the frequency of use are observed. Also, before using the drug, it is necessary to familiarize yourself with the contraindications of the drug in order to exclude the deterioration of the condition.
Method of administration and dosage
Kagocel is administered orally in the prescribed dosage with a small amount of water. The method of administration and dose depends on the age of the person and the state of health. In addition, the purpose of using the drug should be taken into account - for treatment or prevention, which also affects the dose.
With the therapeutic purpose of an infectious disease, for example, influenza or ARVI, in the first 2 days after the acute onset of clinical symptoms, it is recommended to take 2 tablets three times a day. Then, in the next 2 days, you should not take more than 1 tablet three times a day. The duration of the therapeutic course is 4 days, during which a person takes about 18 tablets.
The method of administration and doses for prophylactic purposes are somewhat different. So, to prevent influenza and SARS, it is recommended to take courses. You need to start with a single dose of 2 tablets for 2 days, after which you need to take a break for 5 days. Then repeat the drug intake again and take a break again. Thus, the prophylactic course can last from a week to a month.
For therapeutic purposes, babies from 3 to 6 years old can take 1 tablet twice a day for the first 2 days, after which 1 tablet is enough twice a day for another 2 days. The total duration of the treatment course is 4 days, during which the baby takes 10 tablets.
Children over 6 years old should take 1 tablet three times a day for 2 days, after which the dose is reduced to 1 tablet twice a day, also for 2 days. For 4 days, the child takes 10 tablets.
For prophylactic purposes, the course is carried out in 7-day cycles in children over 6 years old. For 2 days, you should take 1 tablet once a day, after which you need to take a break for 5 days and repeat the reception again. The duration of the preventive course is from a week to a month.
For the treatment of herpes infection, adults need to take 2 tablets three times a day for up to 5 days. The duration of the treatment course is 5 days, during which the total number of tablets is 30 tablets.
When using tablets in the treatment of urogenital chlamydia as an auxiliary drug, it is necessary to observe the dosage of 2 tablets three times a day for 5 days.
Overdose
If the dosages and frequency of administration are observed, an overdose is practically excluded. However, it is still recommended to know the clinical manifestations of an overdose in order to cancel the drug in time and take measures to eliminate the drug as soon as possible.
Overdose may manifest itself as nausea, vomiting, dizziness, weakness and pain in the stomach. In this case, it is recommended to go to the hospital for gastric lavage in a hospital setting, as well as for "forced diuresis".
Gastric lavage is performed in order to remove drug residues that are still in the stomach and stop further drug absorption.
To accelerate the process of removing the drug from the body, it is necessary to carry out detoxification therapy and stimulate the excretion of the drug using furosemide.
In the future, it is necessary to strictly control the dosage in order to avoid re-development of an overdose. This is especially true for babies, since they are most sensitive to various drugs.
Formula, chemical name: Kagocel is a copolymer of carboxymethylcellulose and gossypol (1,6,7-trioxy-3-methyl-5-isopropyl-8-naphthaldehyde).
Pharmacological group: Immunotropic agents / immunomodulators / interferon inducers;
antiviral (with the exception of HIV) drugs.
Pharmachologic effect: antiviral, immunomodulatory.
Pharmacological properties
Kagocel is able to induce the formation of interferon. It causes the production of late interferon, which is a mixture of beta and alpha interferons, which have strong antiviral activity. Kagocel leads to the formation of interferon in almost all cell populations that are involved in the antiviral response of the body: macrophages, B- and T-lymphocytes, granulocytes, endothelial cells, fibroblasts. After ingestion of one dose of the drug, the content of interferon in the blood becomes maximum after 2 days. The body's interferon response to the intake of Kagocel is characterized by a long (up to 5 days) circulation of interferon in the blood. The dynamics of the accumulation of interferon in the intestine after taking the drug does not coincide with that in the blood (in the blood, the content of interferon becomes maximum after 2 days, and in the intestine after 4 hours). The drug in therapeutic doses is non-toxic, does not accumulate in the body. It also does not possess teratogenic, embryotoxic and mutagenic properties, and is not carcinogenic. The maximum efficiency in therapy with Kagocel is possible when it is taken no later than the 4th day from the onset of the disease. For prophylaxis, the drug can be used at any time, including immediately after contact with the source of infection. A day after taking Kagocel, it accumulates mainly in the liver, in the lesser - in the thymus, lungs, spleen, lymph nodes, kidneys. Low concentration is found in adipose tissue, muscles, heart, testes, blood plasma, brain. In the blood, the absorbed drug circulates in a form associated with macromolecules: 37% - with proteins, 47% - with lipids, 16% circulates in an unbound form. It is excreted from the body mainly through the intestines 90%, through the kidneys - 10%.
Indications
Treatment and prevention of influenza and other acute respiratory viral infections in children (from 3 years old) and adults; treatment of herpes (in adults).
Method of application of Kagocel and doses
Kagocel is taken orally, regardless of food intake. Adults: for the treatment of acute respiratory viral infections and influenza: the first 2 days, 24 mg 3 times a day, the next 2 days, 12 mg 3 times a day; for the prevention of influenza and acute respiratory viral infections: 2 days, 1 time per day, 24 mg, break for 5 days, repeat the cycle; for the treatment of herpes: 5 days 3 times a day, 24 mg. Children: for the treatment of acute respiratory viral infections and influenza from 3 to 6 years: the first 2 days, 2 times a day, 12 mg, the next 2 days, 1 time a day, 12 mg; for the treatment of acute respiratory viral infections and influenza from 6 years: the first 2 days 3 times a day, 12 mg, the next 2 days, 2 times a day, 12 mg; prevention of acute respiratory viral infections and influenza in children from 6 years of age: 2 days 1 time per day 12 mg, break 5 days, repeat the cycle. 12 mg = 1 tablet.
If you skip the next intake of kagocel, take it as you remember, the next intake should be performed after a set time from the last use.
To achieve a therapeutic effect, taking the drug must be started no later than 4 days after the onset of the disease.
Contraindications for use
Hypersensitivity, under 3 years of age, pregnancy.
Restrictions on use
There is no data.
Application during pregnancy and lactation
The use of Kagocel is contraindicated during pregnancy. During lactation, when taking Kagocel, it is necessary to stop breastfeeding.
Side effects of kagocel
Allergic reactions are possible.
Interaction of Kagocel with other substances
Kagocel combines well with immunomodulators, antiviral drugs and antibiotics (an additive effect is observed).
Overdose
In case of an accidental overdose with Kagocel, it is necessary to drink plenty of fluids, induce vomiting; if necessary, symptomatic therapy.
- a drug with a pronounced antiviral, antimicrobial, immunomodulatory effect. The drug stimulates the synthesis of alpha, beta and gamma interferons, the action of which is aimed at inhibiting the production of RNA and virus proteins.
The therapeutic effect after the first intake of Kagocel is noted after 4 hours, after which the level of interferons is kept up to 4-5 days. The drug has no toxic effect on the body, does not accumulate in tissues, provided that the recommended dosages are observed.
Kagocel is combined with other drugs: antibiotics, antiviral and antihistamines, drugs that increase immunity. Due to this, Kagocel is used in complex schemes for the treatment of viral diseases.
Instructions for use
ATX code
J05AX, Other Antivirals
Composition and form of release
Tablets, round, biconvex, cream-colored, interspersed. 1 tablet contains Kagocel - 12 mg.
pharmachologic effect
The central mechanism of action of Kagocel is the ability to induce the production of interferon. Kagocel causes the formation of late interferon in the human body, which is a mixture of alpha and beta interferons with antiviral properties.
Kagocel causes the production of interferon in populations of cells participating in the antiviral response of the body: T- and B-lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells.
When one dose of Kagocel is taken orally, the interferon titer in the blood serum reaches a maximum after 48 hours. The body's interferon response to the introduction of Kagocel is characterized by prolonged (up to 4-5 days) circulation of interferon in the bloodstream.
The dynamics of the accumulation of interferon in the intestine when ingested Kagocel does not coincide with the dynamics of the titers of circulating interferon. In the blood serum, the production of interferon reaches its highest values 48 hours after taking Kagocel, and in the intestine, the maximum production of interferon is noted after 4 hours.
Kagocel, when administered in therapeutic doses, is non-toxic, does not accumulate in the body. The drug has no mutagenic and teratogenic properties, is not carcinogenic and has no embryotoxic effect.
The drug is excreted from the body, as a rule, through the intestines: after 7 days after administration, 88% of the administered dose is excreted from the body, including 90% with feces and 10% with urine.
Indications for the use of Kagocel
- prevention and treatment of influenza and other acute respiratory viral infections in adults;
- treatment of influenza and other acute respiratory viral infections in children 3 years of age and older;
- treatment of herpes in adults.
Method of administration and dosage
For oral administration.
Adults
For the treatment of influenza and acute respiratory viral infections, it is prescribed in the first 2 days - 2 tablets 3 times a day, in the next 2 days - 1 tablet 3 times a day. For a course lasting 4 days - 18 tablets.
ARVI prevention is carried out in 7-day cycles: 2 days - 2 tablets once a day, a break for 5 days, then repeat the cycle. The duration of the preventive course varies from 1 week to several months.
For the treatment of herpes in adults, 2 tablets are prescribed 3 times a day for 5 days. For a course lasting 5 days - 30 tablets.
For children
For the treatment of influenza and ARVI, children 3-6 years old are prescribed in the first 2 days - 1 tablet 3 times a day, in the next 2 days - 1 tablet 2 times a day. For a course lasting 4 days - 10 tablets.
For the treatment of influenza and acute respiratory viral infections, children 6 years of age and older are prescribed in the first 2 days - 1 tablet 3 times a day, in the next two days - 1 tablet 2 times a day. Per course - 10 tablets, course duration - 4 days.
Prevention of influenza and ARVI in children 3 years of age and older is carried out in 7-day cycles: two days, 1 tablet once a day, 5 days off, then repeat the cycle. The duration of the preventive course is from one week to several months.
Sometimes the individual prophylactic course of taking the drug is extended up to 5 months.
Contraindications
- pregnancy;
- children under 3 years old;
- increased individual sensitivity.
- lactase deficiency, lactose intolerance or glucose-galactose malabsorption syndrome.
Side effects
Allergic reactions are possible.
Special instructions for use
The effectiveness of the treatment with Kagocel is achieved when the drug is prescribed no later than the 4th day from the onset of an acute infection. For prophylactic purposes, the drug is also used immediately after contact with the infectious agent. Kagocel is combined with other antiviral drugs, immunomodulators and antibiotics.
Drug interactions
With the simultaneous use of Kagocel with other antiviral drugs, immunomodulators and antibiotics, an additive effect has been described.
Interaction of Kagocel with alcohol
Kagocel and alcohol are not combined, so you should not consume alcoholic beverages while treating with this drug.
Storage conditions
Store in a dry, dark place out of the reach of children at a temperature not exceeding 25 ° C.
Shelf life
Vacation conditions
Available without a prescription.
Kagocel's price
The average price is 215 rubles.
Kagocel's analogs
- Amizon;
- Amiksin;
- Arbidol;
- Oscillococcinum;
- Remantadine;
- Tamiflu;
- Cycloferon;
- Citovir.
Kagocel should not be replaced with another medication of your own free will. In the absence of a prescribed drug in the pharmacy network, it is worth seeking advice so that the doctor selects the appropriate drug.
