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Stressful situations and sleep problems are known to everyone. In neglected form, they become sources of many serious diseases. When signs of disturbances in the activity of the nervous system are found, some take a short vacation and try to solve this issue on their own. However, this approach does not always give the desired result. Then medicines come to the rescue, which will be discussed in our ranking of the best and most effective sedatives.

Classification: what are and when are appointed

Constant difficulties at work or in the family can cause emotional overstrain. In order not to start the situation, many resort to the help of sedative drugs. They are divided into two groups:

  • synthetic.

Representatives of the first category are made from natural raw materials, these include all kinds of tinctures and herbs. You can buy them at any pharmacy without a doctor's prescription.

The effect will not be noticeable immediately, but only after a week of regular use of such drugs. They do not harm the body when taken. The result of their application is stored for a long period.

Peony extract, St. John's wort, lemon balm, chamomile, as well as fees, in which several types of plants are present at once, have good soothing properties.

Valerian is very popular. She, according to numerous reviews, perfectly copes with nervous tension and relieves irritability. This remedy is also recommended for migraine, insomnia, heart problems.

Synthetic medicines can only be purchased at a pharmacy. In most cases, they are sold only by prescription. Fast-acting substances have a relaxing effect. At the same time, their long-term use can cause addiction and adverse reactions.

There are the following types of this group of medicines:

  • tranquilizers (prescribed to eliminate anxiety and depressive disorders);
  • antipsychotics (recommended for patients with depression, delusions, hallucinations and disruptions in brain activity);
  • mood stabilizers (normalize the emotional state of people with mental disorders).

It is important to understand that taking sedatives without control can be accompanied by irreversible changes not only in the body, but also in the brain. It is for this reason that before starting the course, it is necessary to consult a specialist.

Over-the-counter sedatives for men and women

Many people are used to self-medication. Once in a critical situation, they seek to find a way out of it themselves. In this case, it is important to know what is not only effective, but also as safe as possible. The following information will help you better navigate modern psycholeptics. By studying the composition of the drugs, their method of application and side reactions, you can avoid unwanted complications.

Representatives of the stronger sex are not used to sharing their problems. Often, they try to survive a stressful state on their own, which is accompanied by nervous tension and a decrease in brain activity. Men can use the following medications: Novo-Passit, Dobrokam, Valemidin, Mens antistress formula.


In the life of women, one of the main roles is played by an unstable hormonal background, which can cause headaches and anxiety. They are recommended the following sedative medicines: "Simpatil", "Phenibut", peony tincture.

Rating of the best sedatives in terms of effectiveness and customer reviews: top 10

The list below is based on customer feedback. It contains the highest quality medicines that calm the nerves, eliminate attacks of aggression and relieve irritability.

  1. "Fitosedan".
  2. "Persen".
  3. "Tenotin".
  4. "Deprim".
  5. "Afobazol".
  6. "Herbion".
  7. "Novo-passit".
  8. "Phenibut".
  9. "Pantogam".
  10. "Glycine".
Category Place Name Rating Price
The best sedatives
products for adults
1 Stress shield 9.8/10 240 r
2 Afobazole 9.3/10 450 r
3 Persen 9.2/10 250 r
4 Peony tincture 9.0/10 10 r
5 Negrustin 8.8/10 250 r
6 Herbion 8.5/10 300 r
7 Novo-passit 8.0/10 200 r
The best sedatives
funds for children
1 Phenibut 9.5/10 350 r
2 Pantogam 9.3/10 500 r
3 Glycine 9.1/10 70 r
4 Syrup "Hare" 8.9/10 200 r
5 Hipp children's tea 8.9/10 300 r

The best sedatives for adults

Troubles at work, difficult relationships in the family, dissatisfaction with one's life and a number of other factors can lead to stressful situations. They are accompanied by the following psychological symptoms: causeless anxiety, depressed mood, internal tension. The medications described below will help to survive stress.

Stress shield

This drug of natural origin is a mixture of the amino acid taurine and herbs: motherwort herb, lemon balm leaves, hawthorn flowers, valerian root extract, St. John's wort herb extract. It is used to eliminate hyperexcitability, normalize sleep and lower blood pressure.

"Stress Shield" has a beneficial effect on the emotional state and nervous system. The collection helps to relax, while its reception does not cause drowsiness. It consists entirely of vegetable raw materials, has a neutral smell and taste.

Pros:

  • natural composition
  • Beneficial effect on the cardiovascular system
  • Calms the nerves
  • Cheap
  • Convenient release form - tablets

Minuses:

  • Due to naturalness, it has a cumulative effect

Afobazole

Anxiolytic, which is widely used to eliminate anxiety and feelings of internal tension caused by stress. It does not affect higher mental functions and does not cause drowsiness. The medicine belongs to the group of tranquilizers and is available in tablets. The dosage is individual. In most cases, doctors prescribe 30 mg per day. The duration of therapy is from a week to one month. The effect is noticeable after a couple of days.

Indications for adoption are the following symptoms: anxiety, smoking cessation syndromes and alcohol withdrawal symptoms, sleep disturbances. Experts recommend using the medicine only to persons over the age of 18.

Pros:

  • Good at dealing with stress
  • Compatible with alcohol in moderate doses
  • Not addictive

Minuses:

  • Not suitable for treating children
  • Contraindicated during pregnancy and lactation
  • The high cost of the drug

Persen

It is of plant origin and contains valerian, lemon balm, peppermint. The drug is recommended for use with increased excitability, insomnia, decreased concentration. When taken in the morning, there will be no feeling of drowsiness.

Pros:

  • Made from herbs
  • Keeps you feeling energized
  • Copes well with increased nervous excitability
  • Helps get rid of insomnia
  • There is a special version for sleep

Minuses:

  • Not suitable for children under 12
  • Not suitable for patients with lactose and fructose intolerance
  • Should not be taken during pregnancy
  • Expensive medicine

Peony tincture

This tool will help bring the nervous system back to normal. It is also prescribed in such serious situations when the patient has frequent epileptic seizures. The tincture has the following effect on the body: it speeds up metabolism, improves the functioning of the central nervous system, sleep, eliminates feelings of tension and anxiety.

Pros:

  • The calming effect lasts for a long time
  • Eliminates insomnia
  • Simple and natural composition: rhizomes, peony grass and ethanol
  • Cheap
  • Can be bought at any pharmacy without a doctor's prescription

Minuses:

  • Not to be used by children under 12 years of age
  • The result appears only a few days after the start of treatment.
  • Strong alcohol odor

Negrustin

This antidepressant is made from plant materials and has antiphobic properties. The active ingredient is St. John's wort extract. The result from the reception appears after about a month. The medicine should be taken in strict accordance with the doctor's instructions.

It is sold in the form of hard gelatin capsules and a solution for internal use. The main feature of the drug is its cumulative effect. In situations where you need to quickly eliminate stress, it will not help. However, its use throughout the course normalizes mood for a long time.

An antidepressant is prescribed for apathy, manic-depressive disorders, a constant feeling of fatigue, a mild form of depression. After taking it, there is no addiction.

Pros:

  • Made on the basis of St. John's wort
  • For a long time brings the general nervous state in order
  • Does not cause inhibition and addiction
  • Not an expensive tool

Minuses:

  • The effect of the treatment appears very slowly
  • Should not be taken in combination with alcohol

Herbion

This effective sedative is sold in the form of drops. It is recommended for patients with increased excitability, sudden attacks of irritability and anger, feelings of fear and internal tension. Contains only natural herbal ingredients that have a mild relaxing effect on the body.

The liquid is diluted in a glass of water and taken orally after a meal. The total therapy time is about 30 days. Reception is contraindicated during the period of gestation and breastfeeding.

Pros:

  • Has a calming effect on the nervous system
  • Helps normalize sleep
  • Composition based on valerian, hops, mint and lemon balm

Minuses:

  • Not suitable for treatment during pregnancy and lactation
  • Contraindicated in gastric ulcer
  • Prolonged use of the drug can be habit-forming

Novo-passit

This is perhaps one of the most popular drugs. It contains 7 different herbs (melissa, valerian, St. John's wort, hawthorn, passionflower, hop fruits, black elderberry), as well as a component of semi-synthetic origin - guaifenesin. The medicine is able to eliminate the anxiety state after the first application. For this reason, it can be used once.

Pros:

  • Treats mild forms of insomnia
  • Eliminates fatigue and irritability
  • Quickly calms nerves
  • Available in the form of tablets and syrup

Minuses:

  • Long list of side effects: nausea, heartburn, diarrhea, dizziness, decreased concentration, allergies
  • High price

Which sedative is best for children

Very often, even babies also need psycholeptics, and this need arises from an early age. They often cannot quickly calm down after receiving new impressions. Some babies do not adapt well to a change in the usual environment, for example, going to kindergarten or school. Regardless of the factor causing overexertion, it is very important to choose the right anxiolytic that will help eliminate the problem and will not harm the child's body.

Phenibut

The nootropic drug is widely used to treat adults and young patients. After the end of therapy, the memory and attention of the child increase. As an active ingredient, the manufacturer added aminophenylbutyric acids to the composition, which have a calming effect and eliminate anxiety.

Pros:

  • Helps to get rid of cramps
  • Eliminates headache
  • Improves blood flow to the brain
  • Promotes healthy deep-eyed sleep

Minuses:

  • May adversely affect the functioning of the stomach
  • Only suitable for children over three years old

Pantogam

Another nootropic that is designed to improve blood circulation in the brain. It is sold in the form of syrup and tablets. Medicines can only be purchased with a doctor's prescription.

The advantages of a sedative include the absence of adverse reactions and small dosages. The medicine can be prescribed to persons with astheno-vegetative syndrome and developmental delays.

Pros:

  • Calms the nerves
  • Increases concentration
  • Strengthens memory
  • Harmless to the body
  • Provides a lasting cumulative effect

Minuses:

  • High price
  • Doesn't work right away
  • In the first days of admission, excessive excitability is possible.

Glycine

A mild sedative, also with long-term use, normalizes the metabolism in the nervous system, reduces anxiety and excitability. Indicated for use during stress and excessive mental stress, for example, during the preparation for exams. Also, the drug helps to cope with aggression, normalizes sleep and fights low mood. The positive aspects include the absence of adverse reactions.

Pros:

  • Eliminates irritability and anxiety
  • Easy to find in pharmacies
  • It's cheap
  • Pleasant taste
  • Regulates hyperactivity
  • Prophylactic against stroke and cancer

Minuses:

  • With frequent use, a negative effect on the kidneys is possible.
  • May cause allergies, drowsiness and nausea

Syrup "Hare"

Designed for children over 3 years of age. The composition includes herbal ingredients:

  • thyme;
  • chamomile;
  • fennel;
  • mint;
  • oregano.

It is sold in the form of a syrup with a pleasant fruity taste, which, according to the instructions, is diluted in a small amount of water.

Pros:

  • The drug is based on herbal collection
  • Sweet to taste
  • Relieves agitation, eliminates tearfulness
  • Soothes the pain
  • The course of admission is only two weeks
  • No contraindications

Minuses:

  • Only for children over three years old
  • Not a drug
  • Relatively high cost

Hipp children's tea

In agreement with the pediatrician, it can be given from the first month of life. The composition includes linden, lemon balm and chamomile. Tea is completely natural and does not contain harmful dyes, flavor enhancers. Moms note that kids drink it willingly.

Pros:

  • Suitable for children of any age
  • Pleasant herbal taste
  • Helps baby sleep

Minuses:

  • With regular use, a jar of tea does not last long
  • May cause caries

If you are interested in the rating of sedatives for children, you can also choose the best option in the Goods catalog. For example, fructose syrup "Altai Mix-2" or herbal collection "Baby. Sleepy".

The best drugs of synthetic origin

If natural herbal remedies do not give the desired result, doctors prescribe stronger medications to treat various disorders of the nervous system. Consider below the most popular of them.

Valoserdin

These drops have a sedative effect and eliminate pain in the heart. The composition includes such active substances as ethyl bromisovalerianate and phenobarbital. Indications for use are insomnia, emotional stress, neuroses, palpitations. Of the positive aspects, a good calming effect and lack of addiction are noted.

Pros:

  • Effectively and quickly calms the nerves
  • Promotes concentration
  • Can be used as a sedative
  • Suitable for long term treatment

Minuses:

  • Not to be used by people with kidney disease
  • Contraindicated in pregnant women and women during breastfeeding
  • A wide list of side effects in overdose

Valemidin

It is sold in the form of drops. The result is manifested already 20 minutes after ingestion: insomnia disappears and the mental state stabilizes. If you take drops on a regular basis, blood pressure will decrease, and pain in the heart will also disappear. The composition includes extract of motherwort, valerian, hawthorn and mint.

Pros:

  • Acts very quickly
  • Provides sound healthy sleep all night long
  • Eliminates nervousness and irritability
  • Can relieve pain
  • Contains natural ingredients

Minuses:

  • It is forbidden to take people with impaired liver and kidney function, heart failure
  • Not recommended for children under 18

The Best Herbal Products

Pharmacology does not stand still, more and more new pills are constantly appearing that can quickly eliminate the negative impact of adverse factors on a person. However, many people prefer traditional methods of treatment and use exclusively herbal remedies. Natural medicines have practically no adverse reactions and have a milder effect on the body.

Deprim

The active substance is St. John's wort extract. This component is used in the fight against depressive disorders of mild and moderate severity. Assign medication to adults and children from 6 years of age. To avoid overdose, do not take it at the same time as other sedatives. Recommended for sleep problems, anxiety and low mood.

Pros:

  • Made from natural ingredients
  • Good for dealing with depression
  • Suitable for treating children and adults
  • Brings the mental state back to normal

Minuses:

  • The effect of taking is not immediately noticeable
  • Will not help with advanced depression

Also pay attention to the series "Healing Gift of Altai" and the dietary supplement "Stress Shield", which you will find in the catalog "Tovariki".

The best homeopathic remedies

Indicated for disorders in the nervous system. Homeopathy has many adherents, while some do not take it seriously. However, when used correctly, such additives will not cause harm.

Tenoten

It is sold in the form of tablets for the treatment of neurotic and neurosis-like conditions, stress disorders, irritability. Its reception has a beneficial effect on the central nervous system, increases the body's resistance to the influence of adverse factors and improves cognitive functions. Can be administered to adults and children from 3 years of age.

Pros:

  • soft action
  • Does not cause drowsiness
  • Improves mood

Minuses:

    • Not to be taken by pregnant women and women during lactation
    • Long term use is addictive

How to save nerves without using medication

  1. Start leading an active lifestyle. Join a gym or swimming pool, do regular physical activity.
  2. Spend more time outdoors.
  3. Get a pet.
  4. Observe the sleep and rest regimen.
  5. Meet up with friends you haven't seen in a while.
  6. Go on a journey and visit new places.
  7. Do what you love.
  8. Try to smile more and look positively at the world.

Remember, no matter what the top 10 best sedatives include, it should be taken with caution and only after consulting a specialist.

Episodic attacks of fear, anxiety, insecurity, nervous breakdowns occur in the life of almost every person. The reason for them is daily stress, from which no one is immune. However, often the nervous system gives serious failures. The state of anxiety is firmly rooted in the mind and becomes a constant companion of life. In this case, you can not do without the help of anti-anxiety drugs. This vast group of psychotropic drugs has been used for a very long time, but not everyone knows how anti-anxiety drugs work and when they should be taken.

What is anxiety and how does it manifest itself?

The state of anxiety is not just a state when a person is worried. With anxiety, many biochemical processes in his body, and above all, in the brain, change.

The source of anxiety is usually stress - the reaction of the nervous system to a difficult or conflict situation, external stimuli. If the stress is light and short-term, then it can even be beneficial for the body, like a kind of shake-up. However, heavy and repetitive stress brings undoubted harm.

With anxiety, a number of somatic symptoms are observed:

  • heart palpitations,
  • rush of blood to the head
  • hyperventilation or shallow breathing
  • shiver,
  • sweating,
  • nausea,
  • diarrhea,
  • increased urge to urinate.

In addition to anxiety, stress leads to irritability, mental imbalance, decreased performance, and depression.

You can try to deal with anxiety and stress on your own. To do this, you need to bring more positive emotions into your life. They can be obtained from playing sports, communicating with people, hobbies. But these funds do not help everyone. In addition, stress can also arise due to objective factors, for example, in severe illnesses. In such cases, there is nothing left but to resort to the help of medications.

This method is no worse and no better than others. There is often an opinion that only the elderly need sedatives and anti-anxiety drugs, and if an adult takes them, then he is either a weak-willed or a drug addict. But this opinion only testifies to medical illiteracy. The work of the nervous system is regulated not by abstract willpower, but by hormones and neurotransmitters, and in some cases biochemical disorders cannot be corrected otherwise than by medication. If a person takes sedatives or anti-anxiety drugs, then he is by no means a drug addict, and cannot become one. In that case, of course, if he complies with the prescriptions of the doctor and the instructions for the remedy prescribed by him.

Behavior modification is often necessary for children and adolescents whose nervous system is very vulnerable and does not have the necessary stability. Very often therapy is required for such nervous disorders in children as hyperactivity, attention deficit disorder, neurosis, rheumatic fever. Women due to hormonal disruptions can also be prone to disorders of the nervous system. Especially often this manifests itself in the form of premenstrual syndrome. At the same time, ladies may experience nervous breakdowns, unmotivated outbursts of aggression.

Of course, you should not rely too much on pills. Treatment of anxiety conditions should be comprehensive and also include lifestyle changes and psychotherapeutic methods.

How do anti-anxiety drugs work?

Human emotions, including anxiety and fear, are controlled by different parts of the brain. But the most important among them is the limbic system - a complex of brain regions, including the thalamus, hypothalamus, amygdala and hippocampus.

Anxiety and fear are among the negative emotions. Therefore, in order to suppress them, it is necessary to weaken the influence of the limbic system on the human psyche.

This effect on the limbic system and carry out anti-anxiety drugs (tranquilizers). They also have other effects:

  • sedative,
  • muscle relaxant (relaxing muscles),
  • anticonvulsant,
  • hypnotic.

The anti-anxiety (anxiolytic) effect of drugs in this group is explained by the effect on the benzodiazepine receptors of brain cells, and through them - on the GABA receptors that inhibit the nervous system.

Muscle relaxant and anticonvulsant effects are explained by the fact that tranquilizers also act on the cells of the spinal cord and inhibit some spinal reflexes.

The depressing effect on the limbic system means that anxiolytics suppress not only negative emotions - fear, anger, anxiety, but also most of the positive ones. The effects of anti-anxiety drugs bring a person into a state of calm and serenity. At the same time, tranquilizers do not affect the cognitive sphere of activity of the brain, do not affect memory. However, the speed of reactions and attentiveness is usually reduced.

Some anxiolytics also have a mild analgesic effect, antiemetic effect, relieve itching.

Anti-anxiety and sedative drugs have a normalizing effect on the autonomic nervous system. Due to this property, they often help to reduce tachycardia, get rid of trembling in the hands, excessive sweating, diarrhea and flatulence.

Most tranquilizers come in tablet form. However, tranquilizers can also be used parenterally.

History of anti-anxiety drugs

Another name for anti-anxiety drugs is anxiolytics. This word in Latin means literally "easing anxiety." Another term often used to refer to anti-anxiety medications is “tranquilizers.” The word tranquilizer comes from the Latin "tranquillo", which means "sedation".

The first tranquilizers were substances of the benzodiazepine class, synthesized in the mid-1950s. First came such drugs as chlordiazepoxide and diazepam. A new class of drugs quickly won the recognition of doctors - psychotherapists, psychiatrists and neurologists, because benzodiazepines had a powerful anxiolytic and sedative effect. Now the lists of tranquilizers have been replenished with the names of many new compounds. And although many anti-anxiety drugs have been created that do not belong to the benzodiazepine class, the latter still retain their importance.

Side effects of anti-anxiety drugs

Nothing is perfect in this world, and tranquilizers are no exception. Shortly after benzodiazepines appeared, some of their shortcomings were discovered. First, it is a number of side effects inherent in them. For the most part, these are effects that are not life-threatening, but seriously reduce a person's ability to work. First of all, this is excessive sedation, increased drowsiness and lethargy, and a decrease in the rate of reactions. This leads to the fact that taking benzodiazepines is contraindicated for those who drive vehicles, complex machines and mechanisms, people involved in work that requires concentration and high reaction speed.

Other possible side effects of benzodiazepines include:

  • confusion (especially in the elderly),
  • depression,
  • dry mouth
  • slurred speech
  • development of hallucinatory psychoses.

Elderly patients are most sensitive to the side effects of benzodiazepines.

Another important drawback of tranquilizers is rapid addiction. This means that over time the dose has to be increased, otherwise the therapeutic effect will not be achieved. In addition, many tranquilizers can lead to drug dependence. Approximately half of patients who take benzodiazepines continuously for 4-6 months develop drug dependence. Dependence on benzodiazepines most easily develops in patients suffering from alcohol and drug dependence, in people suffering from psychopathies and prone to the formation of psychological dependence.

With the termination of long-term therapy with benzodiazepines, a withdrawal syndrome often develops. It can be expressed in the following symptoms:

  • agitation,
  • insomnia,
  • capriciousness,
  • irritability,
  • sweating,
  • shiver,
  • nausea,
  • convulsions (in severe cases).

Therefore, benzodiazepine therapy should not be stopped abruptly when it comes to long-term therapy. The dose of the drug is reduced gradually. If therapy lasted no more than 2 weeks, then its cancellation does not entail any consequences.

All these factors have led to the fact that, according to WHO recommendations, benzodiazepine tranquilizers are not recommended for continuous use for a long time (more than 2-3 weeks). If there is a need for a longer reception, then the course of treatment should be interrupted for several days.

This does not apply to the light and daytime tranquilizer groups. They can be taken continuously for several weeks, or even months, with a doctor's prescription.

If the patient has a history of dependence on benzodiazepines, it is recommended to prescribe antidepressants instead.

However, antidepressants and mild tranquilizers do not have an immediate response, unlike benzodiazepines. The therapeutic effect with the use of mild tranquilizers and antidepressants develops for at least 2 weeks. Also, antidepressants of the SSRI and TCA groups can cause an increase in anxiety symptoms at the very beginning of the intake.

Atypical tranquilizers

There are tranquilizers that are not similar in chemical structure to benzodiazepines, and also favorably differ from them in that they do not have severe side effects and have a completely different mechanism of action.

One such substance is hydroxyzine. This is a rather old remedy, a derivative of diphenylmethane, created back in the 50s, and therefore it cannot be attributed to a new generation of anti-anxiety agents. Compared with benzodiazepines, the drug does not cause addiction and dependence.

Another interesting remedy is buspirone. The drug differs from other tranquilizers in that it does not act on benzodiazepine or GABA receptors, but on serotonin receptors. This drug is also non-addictive and non-addictive. But it also does not lead to drowsiness, lethargy and lethargy.

Meprobamate also belongs to tranquilizers with an atypical mechanism of action. The drug also does not belong to the number of benzodiazepines. According to the chemical structure, meprobamate is a derivative of propanediol. Meprobomate is one of the very first compounds to be used as a tranquilizer.

Can anti-anxiety medications be sold without a prescription?

Anxiolytics are not sold in pharmacies without prescriptions. The only exception is Afobazole, which belongs to the group of light tranquilizers. Almost all tranquilizers belong to the category of psychoactive substances. Therefore, according to the laws, they must be dispensed by prescription. Over-the-counter sedatives can be a definite replacement for prescription anti-anxiety medications:

  • Corvalol;
  • Validol;
  • herbal preparations and dietary supplements based on motherwort, St. John's wort, valerian and other medicinal plants;
  • vitamin complexes containing zinc and magnesium.

Particular attention should be paid to herbal medicines:

  • Persen,
  • Novo-Passit,
  • Motherwort-Forte,
  • Deprim.

Most of them, when used regularly, can help with anxiety conditions of mild severity, mild stress.

New generations of anti-anxiety drugs and daytime tranquilizers

Recently, successful attempts have been made to develop new anxiolytics that do not belong to the benzodiazepine class. The properties of some old compounds are also being re-investigated. This is due to the fact that many doctors are not satisfied with the shortcomings of traditional tranquilizers, which make them unsuitable for continuous use. The result of the activities of researchers was the emergence of a group of so-called daytime tranquilizers. This name is not accidental. Most drugs from the list of daytime anxiolytics do not cause daytime lethargy and drowsiness in patients, do not slow down reactions. And this means that daytime tranquilizers can be used to treat people who lead an active lifestyle, those who drive a car. Daytime tranquilizers also do not cause drug dependence and addiction in the patient.

The main names of daytime tranquilizers:

  • tofisopam (Grandaxin),
  • alprazolam,
  • tazepam,
  • buspirone,

How tranquilizers are selected

There are many factors at play here. Firstly, it is a complex of the patient's symptoms, his diagnosis, the severity of the disease. Much depends on the properties of the drug itself. First of all, doctors pay attention to the time of onset of action and the half-life. If the agent begins to act quickly and has a short half-life, then it is well suited for sedation and as a sleeping pill. Also, benzodiazepines with a rapid onset of action are more suitable for relieving episodic panic attacks. For the treatment of generalized anxiety disorder, panic disorder, benzodiazepines with a long half-life are more suitable. Other advantages of benzodiazepines with a long half-life are the ease of changing the dose, as well as the ease of discontinuation of the drug after long-term treatment.

Pharmacokinetic parameters of some benzodiazepines

Other groups of psychotropic drugs

Not only anxiolytics belong to the class of psychotropic drugs. Affect the nervous system and other types of drugs:

  • sedatives,
  • neuroleptics,
  • normotimics,
  • antidepressants,
  • sleeping pills.

Many of these medications can also relieve a person from anxiety, stress, and fear.

Sedative drugs

The sedative drugs most often include drugs based on plant extracts:

  • menthol,
  • valerian,
  • passionflower,
  • hypericum,
  • motherwort,
  • melissa,
  • hops.

Extracts from this list have long been used in folk medicine as sedatives.

Some synthetic substances, such as phenobarbital, are also effective sedative drugs. There are also some antihistamine drugs with a pronounced sedative effect, for example, Diphenhydramine.

The difference between sedative drugs and tranquilizers is largely arbitrary. However, as a rule, sedative drugs are dispensed without a prescription, but for the purchase of anxiolytics, a doctor's permission is required.

The most popular sedatives:

  • valerian extract,
  • motherwort extract,
  • Corvalol (Valocordin),
  • Validol,
  • Novo-passit,
  • Persen.

Used as sedatives and other herbal preparations. They are usually easier to tolerate by the body, do not overload the liver and kidneys. However, here one must be careful, as many herbal remedies can cause an allergic reaction.

sleeping pills

Sleeping pills are not usually used to relieve anxiety and stress. They are intended for the treatment of sleep disorders. However, often bad is one of the factors leading to the emergence of neurotic disorders. Therefore, as part of the complex therapy of anxiety conditions, hypnotics can be used.

Synthetic hypnotics used to treat sleep disorders include:

  • Zopiclone,
  • Donormil,
  • Diphenhydramine,
  • Trittiko.

Many tranquilizers, such as fenozepam, also have a strong hypnotic effect.

Antidepressants

Antidepressants are often confused with tranquilizers. However, antidepressants have a very different mechanism of action. They affect the concentration in the nerve circuits of the most important neurotransmitters, such as serotonin, dopamine and norepinephrine. However, many antidepressants can also be used to treat anxiety and stress disorders. However, very often doctors prescribe two medications at once - a classic tranquilizer and an antidepressant. The fact is that the effect of antidepressants develops slowly over several weeks. These drugs are more suitable for the treatment of chronic anxiety disorders than benzodiazepine tranquilizers. This is due to the fact that antidepressants do not cause dependence and addiction when taken for a long time, unlike tranquilizers. However, they are not without a withdrawal syndrome, so a long course of antidepressant treatment should be interrupted gradually, with the help of a gradual dose reduction.

Antipsychotics

Antipsychotics are not used to treat anxiety disorders. Their purpose is to relieve symptoms caused by acute psychoses - delusions and hallucinations. Often antipsychotics are used in the treatment of schizophrenia. However, antipsychotics were also formerly called tranquilizers, more precisely, major tranquilizers. But in relation to anxiolytics, the term small tranquilizers was used. However, now such a division of psychotropic substances into small and large tranquilizers is outdated.

Normotimics

Normotimics are a group of compounds that are often used in bipolar disorders. Their purpose is to smooth out the mood swings typical of bipolar affective disorders. They can also be used in the treatment of depression. Normotimics prevent both the appearance of extreme euphoria and depression, despondency, apathy.

Nootropics

Nootropics enhance metabolism in brain cells, improve cerebral circulation. Thus, they increase brain activity, increase memory, and normalize thinking. Many nootropics can also be prescribed for stress, anxiety disorders. And some drugs combine the properties of anxiolytic and nootropic, for example, Phenibut.

Vitamins and trace elements

Vitamins and active biological substances can also be prescribed by neuropathologists, but as part of a comprehensive treatment. Vitamins D, B12, magnesium, zinc are useful for strengthening the nervous system. With a lack in the body of such complex compounds involved in the work of brain cells, like tryptophan, dietary supplements containing them are prescribed.

Beta blockers

Beta blockers do not directly affect the nervous system. However, they are also often used for anxiety disorders. Beta-blockers block the effects of adrenaline on the body and stop many of the symptoms associated with anxiety: increased heart rate, increased sweating.

Indications for anti-anxiety medications

First of all, they are designed to rid a person of negative emotions - anxiety, fear, anxiety, to reduce emotional tension. Tranquilizers also help reduce obsessive thoughts, hypochondria.

They are prescribed mainly for pathologies of the nervous system:

  • anxiety disorders (all types),
  • brief episodes of anxiety
  • anxiety and depression,
  • neurosis,
  • neurotic states,
  • aggression
  • fears
  • stress,
  • nervous tension,
  • phobias
  • mild nervous excitability
  • post-traumatic stress disorder.

Anxiolytics are also used for psychotic disorders, psychosis, obsessive-compulsive disorder. Anti-anxiety and sedative drugs with a pronounced antihistamine effect (Atarax, Diphenhydramine) are used for allergic reactions, skin itching.

In children, tranquilizers are used for neurosis, hyperactivity, attention deficit disorder, enuresis, nightmares, stuttering, rheumochorrhea.

Anxiolytics are also used as part of the treatment of withdrawal symptoms in alcoholism and substance abuse, in menopausal and premenstrual syndromes, chronic fatigue syndrome, and migraines.

The hypnotic properties of anxiolytics make it possible to prescribe them for the treatment of sleep disorders. With these disorders, tranquilizers help lengthen night sleep, make it deeper, allowing the brain to fully rest. The most strongly hypnotic properties are manifested in such tranquilizers as nitrazepam, flunitrazepam, midazolam. The muscle relaxant properties of tranquilizers are used for convulsions and spasms, tetanus, cerebral palsy, excessive muscle tension, and motor agitation. Tranquilizers are also characterized by a decrease in the epileptogenic activity of the brain.

The vegetative-stabilizing function of tranquilizers is also distinguished. It is expressed in the normalization of the activity of the autonomic nervous system. The vegetative-stabilizing activity of tranquilizers leads to a decrease in autonomic symptoms of anxiety (tachycardia, hypertension, sweating). Almost all tranquilizers also have a sympatholytic and mild hypotensive effect, increase the threshold of pain sensitivity.

Anxiolytics are also used for premedication (preparing the patient for operations), as a component of complex anesthesia, to eliminate stress in severe somatic diseases, in psychosomatic diseases (stomach ulcer), as part of the complex treatment of cardiovascular diseases, with pain syndrome.

When tranquilizers are ineffective

Tranquilizers are not effective for delusional, hallucinatory and affective disorders, which can also often be accompanied by fear and anxiety. However, when using antipsychotics, tranquilizers may also be prescribed to prevent their side effects.

Contraindications

Tranquilizers include many drugs with different mechanisms of action. Therefore, contraindications will be individual for each compound. But, as a rule, tranquilizers should not be taken with myasthenia gravis (muscle weakness), respiratory depression, severe liver failure, glaucoma, suicidal tendencies.

Many drugs should not be taken during pregnancy and lactation, in childhood. However, the opinion that any anxiolytics are contraindicated in children is completely unfounded. This is far from true. A number of drugs really can not be used in childhood. However, there are also drugs that can be prescribed to children from a certain age. In this case, a naturally lower dosage is used than in adults. Therefore, if the doctor has prescribed a course of tranquilizers for your child, then this is not a reason to panic. By themselves, tranquilizers in the required dose do not affect the development of the child's brain, do not reduce his intelligence, unlike many diseases of the nervous system, to which children are no less susceptible than adults.

Interaction of tranquilizers with other substances

Tranquilizers enhance the effect of many psychotropic substances. These include antipsychotics, hypnotics and sedatives, antidepressants, histamine receptor blockers. Tranquilizers also enhance the effect of many antihypertensive drugs.

Tranquilizers are incompatible with alpha- and beta-agonists, M-cholinomimetics, psychostimulants. Tranquilizers enhance the inhibitory effect of beta-blockers on the central nervous system.

Many tranquilizers are incompatible with alcohol, since when they are taken, the inhibitory effect of alcohol on the nervous system is enhanced. This can lead to serious consequences, including respiratory depression and loss of consciousness.

Phenazepam

Anxiolytic of the benzodiazepine class, developed in the Soviet Union. In addition to anxiolytic, it also has muscle relaxant, hypnotic and anticonvulsant effects. Anxiolytic action is predominant. Available in tablets with a dosage of 0.5 and 1 mg. Has a high speed of action. It is indicated for emotional lability, fears, anxiety, irritability, emotional overstrain. Contraindicated in childhood.

Afobazole

Light or daytime tranquilizer. These sedative pills are recommended for continuous use, for several months. Afobazole is the only anxiolytic that can be purchased in Russian pharmacies without a prescription. Recommended for mild anxiety, treatment of menopausal syndrome. Afobazol has practically no side effects, it has no sedative effect, it does not cause drowsiness and can be used by patients driving motor vehicles. Dosage - 1 tablet 3 times a day.

Corvalol

Despite its reputation as a heart remedy, Corvalol is predominantly a sedative. The sedative effect is provided by phenobarbital, which is part of Corvalol. Also, the drug has a mild vasodilating and hypnotic effect. Available in the form of a solution or tablets. One of the few synthetic sedatives that can be purchased at pharmacies without a prescription. Corvalol is also popular due to its affordable price. Doctors, however, warn against the constant use of Corvalol for the treatment of anxiety, because phenobarbital has many side effects and causes drug addiction. Corvalol can only be used as a one-time sedative in a situation associated with severe stress or anxiety.

Novo-Passit

Means based on a mixture of medicinal herbs (valerian, St. John's wort, lemon balm, hops, passionflower, elderberry, hawthorn). It has a sedative and hypnotic effect, helps to increase resistance to stress. It is used to treat mild nervous disorders, neurasthenia, fatigue, mild insomnia, migraine, vegetative-vascular dystonia, dermatoses. It is necessary to take 3 tablets for 2 weeks. Contraindications - age up to 12 years, epilepsy, myasthenia gravis.

Persen has a composition similar to Novo-Passit. True, it has fewer herbal components, but the indications for taking both drugs are similar.

Atarax

The active substance is hydroxyzine, which belongs to anxiolytics of a non-benzodiazepine nature. Available in tablets of 25 mg. It has moderate anti-anxiety, antipruritic, sedative, antiemetic, antihistamine effects. The usual dosage is 25 mg per day at night, the maximum daily dosage is 100 mg. The tool is used for anxiety, sleep disorders, skin itching, for premedication. The drug can be used in children from 3 years. Does not cause addiction and dependence.

Tofisopam

The tool is also available under the brand name Grandaxin. These psychotropic pills are classified as mild/daytime tranquilizers. The drug is not addictive or addictive. It has a slight anti-anxiety effect. Improves mood, increases efficiency. Dosage - 50-100 mg 1-3 times a day.

Phenibut

The tool combines the properties of anxiolytic and nootropic. Indications:

  • anxiety states,
  • neurasthenia,
  • insomnia,
  • anxiety,
  • fear,
  • mild depression,
  • dizziness.

The minimum course of treatment with the drug is 2 weeks. Dosage - 3 times a day for 0.5 g.

Gorzdrav is a pharmacy chain with more than 750 branches located in Moscow, St. Petersburg, Moscow Region and the Leningrad Region. To easily place an order for sedatives for the nervous system, you do not need to leave your home: find the necessary medicine in the list on our website, put it in the Basket and pick it up at the nearest pharmacy to your home. The goods are paid at the checkout in cash or by credit card. Before making a purchase, carefully study the information about the medication: its pharmacological properties, indications and contraindications, dosage and usage patterns. If necessary, consult with a specialist.

The use of sedatives

Calming drugs for the nervous system reduce the body's response to external stimuli and emotional exhaustion, and to some extent reduce daily activity. Such medications, including those without addiction, regulate the activity of the central nervous system, extinguishing the processes of excitation and enhancing the processes of inhibition. Medicines deepen natural sleep for recuperation. [i]i They are generally non-addictive and are prescribed to both adults and children for the following disorders of the nervous system:

  • neuroses and neurasthenia;
  • Psycho-emotional disorders;
  • Increased anxiety;
  • Insomnia;
  • hyperexcitability;
  • Disorders of the cardiovascular system and gastrointestinal tract;
  • Panic attacks.

Each drug has its own indications and contraindications, so before buying, carefully read the instructions for use and follow the doctor's recommendations. If taken incorrectly, adverse reactions may occur.

Release forms

The catalog of the site "Gorzdrav" presents drugs for the central nervous system in different forms of release:

  • Calming pills for the nervous system;
  • Vitamins (including effervescent);
  • syrups;
  • Capsules;
  • Solutions for injections in ampoules;
  • Dragee;
  • Powders.

For whom

On our site you will find sedatives for the nervous system:

  • adult;
  • Teenager;
  • child;
  • An elderly person.

Contraindications

In order for the medicine for the central nervous system to bring only benefit, it must be remembered that sedatives have a number of contraindications. These include:

  • Increased individual sensitivity to the active substance;
  • Acute disorders of cerebral circulation;
  • Renal and liver failure;
  • Predisposition to the development of bleeding.

During pregnancy and lactation, you can take medicines only on the advice of a doctor. Young children should not be given drugs intended for adults.

Certificates

Some certificates of goods presented in our catalog.

BEFORE USING THE DRUGS, READ THE INSTRUCTIONS FOR USE OR CONSULT WITH A SPECIALIST.

Bibliography:

  1. [i] Pharmacology, under. ed. Yu. F. Krylov and V. M. Bobyrev. - Moscow, 1999. > 2. Private pharmacology > 2.1. Neurotropic agents > 2.1.3. Medicinal products acting on the central nervous system > 2.1.3.5. Calming agents

Content

If necessary, relax, quickly calm the nervous system, a person resorts to medicine. In modern pharmacology, a number of reliable medicines have been declared that really help to find peace of mind. It remains only to find out from the attending physician which sedative is the most effective and safe.

Sedatives for the adult nervous system

When choosing a reliable remedy for nerves, the first step is to understand the cause of the internal imbalance. For example, some patients can take sedatives, while others cannot cope without the help of tranquilizers. It all depends on the etiology of the pathological process, the internal characteristics of the organism. There are enough fast-acting options in the pharmacy, most of them are sold without a prescription, but this does not mean at all that superficial self-medication is appropriate.

For women

Representatives of the weaker sex are more likely to have such emotional experiences as inner fear, unreasonable anger, panic, excessive fussiness and increased nervousness. To eliminate such unpleasant symptoms, it is required to choose a potent drug to stabilize the shattered psyche. The best sedative for women will be prompted by a neurologist, below are good options in a given direction:

  1. Persen is a herbal sedative, produced in tablets and liquid form (syrup). It has a pleasant taste, affordable cost and fast action in the female body. Works without side effects.
  2. Novopassit is a herbal preparation that helps to overcome internal stress. Available in tablets, it is inexpensive, it works after the first dose. In the natural composition of valerian, St. John's wort, lemon balm, hawthorn and hops.
  3. Afobazole is a potent anxiolytic, produced in the form of white tablets. It costs an order of magnitude more expensive than its "competitors", but it also acts unmistakably on the focus of pathology. Take 1 pill three times a day, a sedative effect is provided.

For men

Representatives of the stronger sex also know how to be nervous, and how. Recall at least situations on the road when obscene abuse is heard from the car. Yes, and at work there is also enough stress, you need to calm down. This requires an anti-stress drug that does not cause the side effects of drowsiness and loss of concentration. The best sedative for men, including avid motorists, is the following:

  1. Tenoten is a good remedy for increased excitability, a tendency to psychosis and hysteria. It is necessary to take 2 pills per day in order to feel emotional balance in a couple of days. The course of therapy is up to 2 weeks.
  2. Teravit Antistress is a multivitamin complex with a mild effect on the nervous system. It acts without harm to health, additionally strengthens the immune system, increases the body's resistance to stress.
  3. Atarax are tranquilizers for adults that help to cope with inner fear, inferiority complex, panic attacks. It is prescribed for alcoholism in case of psychomotor agitation.

Sedatives for teenagers

With a transitional age, the need for such medications may arise. Before starting the course, it is required to consult with a pediatric neurologist, to determine worthwhile sedatives for the adolescent's nervous system. The main evaluation criteria are high efficiency, safety, long-term effect. Here are the best examples:

  1. Herbion (psyllium syrup) is a homeopathic cough remedy that can be used to calm the nervous system after a long illness. The cough reflex becomes less intense, the patient mentally calms down, sleeps better.
  2. Glycine is a combined drug for improving memory, which is especially important in adolescence. In addition, tablets are a powerful sedative, and their use eliminates cases of overdose and side effects. Many students drink them. Find out what others are and how to take them.
  3. Phytosedan is a homeopathic sedative collection, which contains herbs that relax smooth muscles. It is desirable to take a drink at night in order to regulate the phase of sleep, to gain emotional peace.

Sedatives for the nervous system of the child

Mental problems in childhood are difficult to avoid, so parents should always "keep their finger on the pulse", and in case of prerequisites for early psychosis or hysteria, on the recommendation of a doctor and instructions, immediately give a sedative to children. It is important to be selective in the choice of medicines for a small patient, and still give preference to homeopathy. Pediatric neurologists recommend such excellent sedatives:

  1. Valerian or motherwort are soothing decoctions that inhibit the passage of a nerve impulse. This means that an acute reaction to everything that happens is relegated to the background, the child behaves calmly.
  2. Phenibut is a harmless sedative approved for use in children. Successfully treats inner fear, anxiety, normalizes sleep, eliminates the causes of stuttering. Available in the form of tablets, a single dose depends on the age of the patient - from 50 to 250 ml.
  3. Nervocheel - soothing pills for nerves, harmless in childhood. They are prescribed by a neurologist, are not addictive, are allowed even when breastfeeding. They will help relieve stress within a quarter of an hour after taking a single dose.

Sedative drugs

There are several pharmacological groups that represent good sedative pills at different prices. These can be representatives of homeopathy, sedatives, nootropics, even tranquilizers. The differences are in the therapeutic effect and the final result that awaits after taking the patient. It is necessary to study each group separately in more detail.

For depression and neurosis

  1. Tenoten - relieves stress, removes internal anxiety. Sedatives are available for depression in tablets and alcohol solution.
  2. Persen is a herbal anti-anxiety drug, take 2-3 tablets three times a day, regardless of the meal.
  3. Afobazole is a tranquilizer in the form of small white tablets. 1 pill three times a day for a two-week course.

Under stress, not causing drowsiness

  1. Quattrex is a tranquilizer. Removes mental confusion, increases physical activity, improves the psychological performance of the body.
  2. Adaptol is a sedative for stress that does not cause spleen and drowsiness. The name corresponds to its pharmacological properties.
  3. Nervoflux is a herbal collection that invigorates and tones an organic resource, has an affordable price and herbal ingredients.

Without prescriptions

  1. Afobazole is a tranquilizer with an average price of 450-500 rubles. It works powerfully, a prescription is not required in a pharmacy to buy.
  2. Phenibut is a compromise option at a cheap price - 150-200 rubles. The drug is effective, eliminates mental disorders at any age.
  3. Valocordin is a strong over-the-counter sedative that comes in the form of drops to be taken by mouth. It is better not to violate the daily doses; the weight of the patient is taken into account when prescribing.

From stress and anxiety

  1. Atarax is the best tranquilizer for anxiety conditions, which helps to get rid of excitement, insomnia, blues and stress. It is necessary to drink 1 pill three times a day.
  2. Grandaxin is a sedative that helps with mental disorders, physical weakness and emotional instability. There are restrictions in the instructions.
  3. Glycine - harmless pills, sedatives, they save from stress, anxiety and nervous tension already on the third day of daily intake. Allowed for children, pregnant, lactating.

On herbs

  1. Neuroplant is a phytopreparation that eliminates signs of depression. If you drink a single dose, a sedative effect immediately sets in, a feeling of detachment.
  2. Dormiplant - analogue tablets, provided that an acute allergic reaction develops to the active components of the predecessor.
  3. Deprim is herbal sedative pills that productively fight bad mood, depression, blues and apathy, remove the symptoms of VVD.

From panic attacks

  1. Phenazepam - pills for panic attacks, prescribed for exacerbation of phobias, hypochondriacal symptoms and nightmares.
  2. Gidazepam is a daytime tranquilizer that can be taken while driving. Helps to concentrate well, better adapt to the traffic situation.

From irritability and nervousness

  1. Perselac replenishes the list of herbal remedies with a sedative, hypnotic effect. Relieves insomnia, well calms the nervous system irritated to the limit.
  2. Motherwort Forte is a natural preparation that can even prevent a nervous breakdown. It has a convenient form of release - tablets for irritability and nervousness, you can prepare a decoction.
  3. Magnelis - prevention for the nervous system, enrichment of cells with valuable microelements and minerals, nourishment of the brain.

Cheap sedatives

Good drugs mean expensive... This is a misconception, given the price of individual sedatives. Inexpensive sedatives can be selected from the catalog, ordered and bought in the online store. If the possibilities of the virtual web are not available, the pharmacy also has acceptable budget options for all age categories. This is:

  • Motherwort;
  • Valerian;
  • Glycine;
  • Morozov drops;
  • green drops.